Selected Publications


A full and up-to-date publication list is available at Google Scholar.


Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.

Harripaul R, Rabia A, Vasli N, Mikhailov A, Rodrigues A, Pastore SF, Muhammad T, Madanagopal TT, Hashmi AN, Tran C, Stan C, Aw K, Zai CC, Azam M, Mahmood S, Heidari A, Qamar R, French L, Tripathy SJ, Agha Z, Iqbal M, Ghadami M, Santangelo SL, Bozorgmehr B, Al Ayadhi L, Sasanfar R, Maqbool S, Hassan A, Knowles JA, Ayub M, Vincent JB.
Scientific Reports

2026
DOI

Molecular architecture of human dermal sleeping nociceptors.

Korner J, Howard D, Solinski HJ, Mancilla Moreno M, Haag N, Fiebig A, Maxion A, Bhuiyan SA, Toklucu I, Bott RA, Sankaranarayanan I, Tavares-Ferreira D, Shiers S, Inturi NN, Eberhardt E, Ernst L, Bonaguro L, Schulte-Schrepping J, Beyer MD, Stiehl T, Renthal W, Kurth I, Tigerholm J, Serra J, Price TJ, Schmelz M, Namer B, Tripathy SJ*, Lampert A*.
Cell

2026
PubMed

A Novel Polygenic Risk Score Indexing Somatostatin-Expressing Inhibitory Neurons Predicts Somatostatin-Expressing Cell Proportions and Severity of Symptoms in Late-Life Depression.

Dos Santos FC, Zhou X, Clifford KP, Gonzalez Segura A, Syeda AS, Felsky D, Lenze EJ, Mulsant BH, Tripathy SJ, Sibille E, Nikolova YS.
Biological Psychiatry Global Open Science

2026
DOI

Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers.

Guet-McCreight A, Tripathy SJ, Sibille E, Hay E.
Aging Cell

2026
DOI

Cortical GABAergic Neuron Dysregulation in Schizophrenia Is Age Dependent.

Kiss D, Zhou X, Endresz N, Arbabi K, Gonzalez Segura A, Felsky D, Diaconescu AO, Sibille E, Tripathy SJ.
Biological Psychiatry Global Open Science

2026
DOI

Spatial dynamics of cellular and molecular plasticity in the maternal and postpartum mouse brain.

Arbabi K*, Ghazisaeidi S*, Kukreja B, Feng MY, Hudson H, Fafouti ME, Galea L, Tripathy SJ, Kalish BT.
bioRxiv

2026
bioRxiv

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms.

Xu N, Rynard KM, Radley E, Tian A, Arshad M, Long C, Li J, Luo H, Hogan E, Fafouti ME, Davie M, Naimi F, Li Y, Calarco JA, Trost B, Muffat J, Lee HO, Lipshitz HD, Smibert CA, Tripathy SJ.
bioRxiv

2025
bioRxiv

Hyperpolarization-activated cation channel mediated intrinsic plasticity changes underlie the malleability of within cell-type electrophysiological heterogeneity.

Moradi Chameh H, Falby M, Yang Y, Movahed M, Arbabi K, Sarathy C, Tripathy SJ, Zhang L, Lefebvre J, Valiante TA.
bioRxiv

2025
bioRxiv

Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer’s disease.

Hamid M, Saha Detroja T, Tripathy SJ, Menon V, Xu J, Yu L, Wang Y, Buchman AS, Bennett DA, De Jager PL, Lim ASP.
Brain

2025
DOI

ASiDentify (ASiD): a machine learning model to predict new autism spectrum disorder risk genes.

Rynard KM, Han K, Wainberg M, Calarco JA, Lee HO, Lipshitz HD, Smibert CA, Tripathy SJ.
Genetics

2025
DOI

A Transcriptomic Signature of Depressive Symptoms in Late Life.

Matan-Lithwick S, Misztal MC, Yang M, DeLong T, Tripathy SJ, Dunn JT, Bennett DA, De Jager PL, Wang Y, Fisher DW, Dong H, Felsky D.
Biological Psychiatry Global Open Science

2025
DOI

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics.

Koch NA, Corrigan BW, Feyerabend M, Gulli RA, Jimenez-Sosa MS, Abbass M, Sunstrum JK, Matovic S, Roussy M, Luna R, Mestern SA, Mahmoudian B, Vijayraghavan S, Igarashi H, Pradeepan KS, Assis WJ, Pruszynski JA, Tripathy SJ, Staiger JF, Gonzalez-Burgos G, Neef A, Treue S, Everling S, Inoue W, Khadra A, Martinez-Trujillo JC.
Cell Reports

2025
DOI

Molecular Signatures of Early-Onset Bipolar Disorder and Schizophrenia: Transcriptomic and Machine-Learning Insights into Calcium and cAMP Signaling, Including Sex-Specific Patterns.

Afjeh SS, Dey S, Kiss D, Sanches M, Dos Santos F, Pouget JG, Akbarian N, Tripathy SJ, Goncalves VF, Kennedy JL.
International Journal of Molecular Sciences

2025
DOI

Single neuron diversity supports area functional specialization along the visual cortical pathways.

Feyerabend M*, Pommer S*, Jimenez-Sosa MS, Rachel J, Sunstrum JK, Preuss F, Mestern S, Hinkel R, Mietsch M, Vijayraghavan S, Everling S, Treue S, Arnsten AF, Lewis DA, Tripathy SJ, Gonzalez-Burgos G, Inoue W, Neef A, Staiger JF, Martinez-Trujillo JC.
bioRxiv

2024
bioRxiv

Neonatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography.

Tahmasian N, Feng MY, Arbabi K, Rusu B, Cao W, Ning S, Leung JWH, Kukreja B, Wainberg M, Tripathy SJ*, Kalish BT*.
eNeuro

2024
DOI

Reported race-associated differences in control and schizophrenia post-mortem brain transcriptomes implicate stress-related and neuroimmune pathways.

Simmons S, Arbabi K, Felsky D, Wainberg M, Tripathy SJ.
Frontiers in Molecular Neuroscience

2024
DOI

Transcriptomic pathology of neocortical microcircuit cell types across psychiatric disorders.

Arbabi K*, Newton DF*, Oh H, Davie MC, Lewis DA, Tripathy SJ*, Sibille E*.
Molecular Psychiatry

2024
DOI

CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease.

Rybnicek J, Chen Y, Milic M, De Jager PL, Schneider JA, Bennett DA, Tripathy SJ*, Felsky D*, Lambe EK*.
Translational Psychiatry

2024
DOI

Genetic architecture of the structural connectome.

Wainberg M, Forde NJ, Salim Mansour S, Medland SE, Hawco C, Tripathy SJ.
Nature Communications

2024
DOI

Integrating single-cell and spatially resolved transcriptomic strategies to survey the astrocyte response to stroke in male mice.

Scott EY, Safarian N, Ali S, Dryden M, Tockovska T, Casasbuenas DL, Peng J, Emerson D, Tripathy SJ*, Yuzwa S*, Wheeler A*, Faiz M*.
Nature Communications

2024
DOI

Opposing brain signatures of sleep in task-based and resting-state conditions.

Abdelhack M, Zhukovsky P, Milic M, Harita S, Wainberg M, Tripathy SJ, Griffiths JD, Hill SL, Felsky D.
Nature Communications

2023
DOI

Distinctive Biophysical Features of Human Cell-types: Insights from Studies of Neurosurgically Resected Brain Tissue.

Moradi Chameh H, Falby M, Movahed M, Arbabi K, Rich S, Zhang L, Lefebvre J, Tripathy SJ, De Pitta M, Valiante TA.
Frontiers in Synaptic Neuroscience

2023
DOI

Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse Patch-seq datasets.

Arbabi K, Jiang Y, Howard D, Nigam A, Inoue W, Gonzalez-Burgos G, Felsky D, Tripathy SJ.
iScience

2023
DOI

Shared genetic risk loci between Alzheimer’s disease and related dementias, Parkinson’s disease and amyotrophic lateral sclerosis.

Wainberg M, Andrews SJ,Tripathy SJ
Alzheimer's Research and Therapy

2023
PubMed

Case-control virtual histology elucidates cell types associated with cortical thickness differences in Alzheimer's disease.

Kerrebijn I, Wainberg M, Zhukovsky P, Chen Y, Davie M, Felsky D, Tripathy SJ.
NeuroImage

2023
PubMed

Robust differences in cortical cell type proportions across healthy human aging inferred through cross-dataset transcriptome analyses.

Chen Y, Hunter E, Arbabi K, Guet-McCreight A, Consens M, Felsky D, Sibille E, Tripathy SJ.
Neurobiology of Aging

2023
PubMed

Identification of Brain Cell Types Underlying Genetic Risk for Reading and Correlated Traits.

Price KM, Wigg KG, Nigam A, Blokland K, Wilkinson M, Kerr EN, Guger SL, Lovett MW, Strug SJ, Tripathy SJ, Barr CL.
Molecular Psychiatry

2023
PubMed

Chrna5 is a marker of cholinergic super-responder subplate neurons in prefrontal cortex with specialized expression of nicotinic modulator proteins.

Venkatesan S, Chen T, Liu K, Turner EE, Tripathy SJ, Lambe EK.
iScience

2023
PubMed

Bigenomic association study of accelerometer-derived and self-reported sleep properties across UK Biobank participants with lifetime major depressive disorder.

Beaupre LM, Wainberg M, Tiwari A, Zai C, Brown G, Byrne EM, Tripathy SJ, Kennedy JL, Vanessa Gonçalves V.
Journal of Psychiatric Research

2022
PubMed

Sex-specific associations of cardiovascular disease with lifetime diagnosis of bipolar disorder: A cross-sectional analysis of 257,673 participants from the UK Biobank.

Ortiz A, Sanchez M, Abdelhack M, Schwaiger TR, Wainberg M, Tripathy SJ, Felsky D… Fiedorowicz JG.
J Affect Dis

2022
PubMed

An in vitro whole-cell electrophysiology dataset of human cortical neurons.

Howard D*, Chameh HM*, Guet-McCreight A, Hsiao HA, Vuong M, Seo YS, Shah P, Nigam A, Chen Y, Davie M, Hay E, Valiante TA*, Tripathy SJ*
GigaScience

2022
PubMed

Age-dependent increased sag current in human pyramidal neurons dampens baseline activity and noise in cortical processing.

Guet-McCreight A, Chameh HM, Mahallati S, Wishart M, Tripathy SJ, Valiante TA, Hay E.
Cereb Cortex

2022
PubMed

Fragmentation of Rest Periods, Astrocyte Activation, and Cognitive Decline in Older Adults With and Without Alzheimer’s Disease.

Wu R, Tripathy S, Menon V, Yu L, Buchman A, Bennett D, De Jager P, Lim ASP.
Alzheimer’s and Dementia

2022
PubMed

Identification of endocannabinoid predictors of treatment outcomes in major depressive disorder: A Canadian Biomarker Integration Network for Depression (CAN-BIND) study.

Kim HK, Wainberg M, Zai G, Mueller D, Husain MI, Lam RW, Frey BN, Soares C, Parikh S, Milev R, Foster JA, Turecki G, Farzan F, Uher R, Mulsant BH, Kennedy S, Tripathy SJ, Kloiber S.
Pharmacopsychiatry

2022
PubMed

Bulk and Single-nucleus Transcriptomics Highlights Intra-telencephalic and Somatostatin Neurons in Alzheimer’s Disease.

Consens M, Chen Y, Menon V, Wang Y, Schneider JA, De Jager PL, Bennett DA, Tripathy SJ, Felsky D.
Frontiers in Mol Neuro

2022
PubMed

Multiscale neural signatures of major depressive, anxiety, and stress-related disorders.

Zhukovsky P., Wainberg, M., Milic M., Tripathy, S.J., Mulsant B.H., Felsky D., Voineskos, A.N.
Proceedings of the National Academy of Sciences

2022
PubMed

Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge.

Wainberg M, Merico D, Keller MC, Fauman EB, Tripathy SJ.
Molecular Psychiatry

2022
PubMed

Neurobiological, familial and genetic risk factors for dimensional psychopathology in the Adolescent Brain Cognitive Development study.

Wainberg M, Jacobs G, Voineskos AN, Tripathy SJ.
Molecular Psychiatry

2022
PubMed

LaminaRGeneVis: a tool to visualize gene expression across the laminar architecture of the human neocortex.

Kim, E. H., Howard, D., Chen, Y., Tripathy, S. J.*, & French, L.*
Frontiers in Neuroinformatics

2022
PubMed

Bulk and Single-nucleus Transcriptomics Highlight Intra-telencephalic and Somatostatin Neurons in Alzheimer's Disease.

Consens, M.E., Chen, Y., Menon, V., Wang, Y., Schneider, J.A., De Jager, P.L., Bennett, D.A., Tripathy, S.J.* and Felsky, D.*
Frontiers in Molecular Neuroscience

2022
PubMed

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits.

Yao, H.K., Guet-McCreight, A., Mazza, F., Chameh, H.M., Prevot, T.D., Griffiths, J.D., Tripathy, S.J., Valiante, T.A., Sibille, E. and Hay, E.
Cell reports

2022
PubMed

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types

Gillespie, T.H., Tripathy, S.J., Sy, M.F. Martone M.E., Hill S.L.
Neuroinformatics

2022
PubMed

Neurobiological, familial and genetic risk factors for dimensional psychopathology in the Adolescent Brain Cognitive Development study.

Wainberg, M., Jacobs, G.R., Voineskos, A.N. and Tripathy, S.J.
Molecular Psychiatry

2022
PubMed

Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge.

Wainberg, M., Merico, D., Keller, M.C., Fauman, E.B. and Tripathy, S.J.
Molecular Psychiatry

2022
PubMed

Deletion of Loss-of-Function–Intolerant Genes and Risk of 5 Psychiatric Disorders.

Wainberg M, Merico D, Huguet G, Zarrei M, Jacquemont S, Scherer SW, Tripathy SJ.
JAMA Psychiatry

2022
PubMed

Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank.

Wainberg, M., Jones, S.E., Beaupre, L.M., Hill, S.L., Felsky, D., Rivas, M.A., Lim, A.S., Ollila, H.M. and Tripathy, S.J.
PLoS Medicine

2021
PubMed

Clinical laboratory tests and five-year incidence of major depressive disorder: a prospective cohort study of 433,890 participants from the UK Biobank.

Wainberg, M., Kloiber, S., Diniz, B., McIntyre, RS., Felsky, D., Tripathy, SJ.
Transl Psychiatry

2021
PubMed

Symptom dimensions of major depression in a large community-based cohort.

Wainberg M, Zhukovsky P, Hill SL, Felsky D, Voineskos A, Kennedy S, Hawco C, Tripathy SJ
Psychological Medicine

2021
PubMed

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences.

Moradi H, Rich S, Wang L, Chen FD, Zhang L, Carlen PL, Tripathy SJ*, Valiante TA*
Nature Communications

2021
PubMed

Cannabis, schizophrenia genetic risk, and psychotic experiences : A cross-sectional study of 109,308 participants from the UK Biobank.

Wainberg M, Jacobs GR, di Forti M, Tripathy SJ
Translational Psychiatry
Press

2021
PubMed

Estimating and Correcting for Off-Target Cellular Contamination in Brain Cell Type Specific RNA-Seq Data.

Sicherman J, Newton D, Pavlidis P, Sibille E, Tripathy SJ
Frontiers in Molecular Neuroscience

2021
PubMed

Patch-seq: Past, Present, and Future.

Lipovsek M, Bardy C, Cadwell CR, Hadley K, Kobak D, Tripathy SJ
Journal of Neuroscience

2021
PubMed

Consequences of NMDA receptor deficiency can be rescued in the adult brain.

Mielnik C, Binko M, Chen Y, Funk A, Johannsson E, Katheron I, Sivananthan N, Islam R, Milenkovic M, Horsfall W, Ross R, Groc L, Salahpour A, McCullumsmith M, Tripathy SJ, Lambe E, Ramsey AJ.
Molecular Psychiatry

2020
PubMed

Assessing the molecular overlap between human major depressive disorder and three mouse models of chronic stress.

Tripathy SJ
Biological Psychiatry

2020
PubMed

Single nucleus RNA sequencing implicates OPCs and deep layer excitatory neurons in the pathophysiology of major depression.

Nagy C, Maitra M, Tanti A, Suderman M, Theroux JF, Davoli MA, Perlman K, Yerko V, Tripathy SJ, Pavlidis P, Mechawar N, Ragoussis J, Turecki G
Nature Neuroscience

2020
PubMed

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types.

Gillespie TH, Tripathy SJ, Sy MF, Martone ME, Hill SL

2020
bioRxiv

Transcriptomic correlates of electrophysiological and morphological diversity within and across neuron cell types.

Bomkamp C*, Tripathy SJ*, Bengtsson Gonzales C, Hjerling-Leffler J, Craig AM, Pavlidis P. PLoS Computational Biology.

2019
PubMed

Transcriptomic evidence for alterations in astrocytes and parvalbumin interneurons in five cohorts of schizophrenia and bipolar subjects

Toker L, Mancarci BO, Tripathy SJ, Pavlidis P. Biological Psychiatry.

2018
PubMed

Assessing transcriptome quality in patch-seq datasets.

Tripathy SJ, Toker L, Bomkamp C, Mancarci O, Belmadani M, Pavlidis P. Frontiers in Cellular Neuroscience.

2018
PubMed

Modeling sources of inter-laboratory variability in electrophysiological properties of mammalian neurons.

Tebaykin D*, Tripathy SJ*, Binnion B, Li B, Gerkin RC, Pavlidis P. Journal of Neurophysiology.

2017
PubMed

Cross-laboratory analysis of brain cell type specific transcriptomes with applications to bulk tissue data.

Mancarci BO, Toker L, Tripathy SJ, Li B, Rocco B, Sibille E, Pavlidis P. eNeuro.

2017
PubMed

Transcriptomic correlates of neuron electrophysiological diversity.

Tripathy SJ, Toker L, Li B, Crichlow CL, Tebaykin D, Mancarci O, Pavlidis P. PLoS Computational Biology.

2017
PubMed

Neurodata Without Borders: Creating a Common Data Format for Neurophysiology.

Teeters JL, ...Tripathy SJ, ... Svoboda K, Sommer FT. Neuron.

2015
PubMed

Agile text mining with Sherlok.

Richardet R, JC Chappelier, Tripathy SJ, Hill S. IEEE Big Data.

2015
PubMed

Brain-wide analysis of electrophysiological diversity yields novel categorization of mammalian neuron types.

Tripathy SJ, Burton SD, Geramita M, Gerkin RC, Urban NN. Journal of Neurophysiology.

2015
PubMed

NeuroElectro: a window to the world’s neuron electrophysiology data.

Tripathy SJ, Savitskaya J, Burton SD, Urban NN, Gerkin RC. Frontiers in Neuroinformatics .

2014
PubMed

Intermediate intrinsic diversity enhances neural population coding.

Tripathy SJ, Padmanbhan K, Gerkin RC, Urban NN. PNAS.

2013
PubMed

Recent News

Feb 4, 2026

Derek Howard's paper on sleeping pain neurons published in Cell!

Dec 20, 2025

TripLab Winter Holiday Party 2025

Sep 29, 2025

Celebrating Dan Kiss's paper on GABAergic neuron dysregulation in schizophrenia

Aug 21, 2025

TripLab Summer Party at Shreejoy's House

Apr 3, 2025

TripLab Goes Bowling